The Claim
Short-term oral supplementation with ketone monoester (300 mg/kg three times daily for 5 days) in healthy young adults increases glomerular filtration rate by 6.0 mL/min and urinary sodium excretion by 69 μmol/min while reducing urinary potassium excretion by 31 μmol/min during acute measurement periods, indicating that exogenous ketosis directly alters renal hemodynamics and electrolyte handling without changing total 24-hour sodium or potassium balance.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
Oral ketone monoester supplementation in healthy young adults increases kidney filtration rate and sodium excretion while decreasing potassium excretion during acute measurement periods, without altering total daily sodium or potassium balance.
See the scientific wording
Short-term oral supplementation with ketone monoester (300 mg/kg three times daily for 5 days) in healthy young adults increases glomerular filtration rate by 6.0 mL/min and urinary sodium excretion by 69 μmol/min while reducing urinary potassium excretion by 31 μmol/min during acute measurement periods, indicating that exogenous ketosis directly alters renal hemodynamics and electrolyte handling without changing total 24-hour sodium or potassium balance.
Ketones in the blood cause the kidney's filtering vessels to widen, increasing blood flow and filtration rate. This floods the kidney's filtering units with more fluid and sodium, which the tubules cannot fully reabsorb. At the same time, the slightly more acidic blood blocks the kidney's ability to release potassium into the urine. The body tries to hold onto sodium by activating a backup system, but it cannot fully reverse the initial sodium loss.
What the research says
1 studyTaking this ketone supplement for five days temporarily made the kidneys filter blood faster and flush out more sodium while holding onto more potassium — but over a full day, the total amount of sodium and potassium in the body didn’t change.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.