The Claim

Daily supplementation with 1500 mg of creatine hydrochloride for 8 weeks improves reaction time in perimenopausal and menopausal women.

Source: The Effects of 8-Week Creatine Hydrochloride and Creatine Ethyl Ester Supplementation on Cognition, Clinical Outcomes, and Brain Creatine Levels in Perimenopausal and Menopausal Women (CONCRET-MENOPA): A Randomized Controlled Trial.

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
59score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

Cause and effect
1 study reviewed
In plain English

A study found that taking 1500 mg of creatine hydrochloride daily for 8 weeks improves reaction time in women going through perimenopause or menopause. The improvement was significantly greater than in a placebo group.

See the scientific wording

Daily supplementation with 1500 mg of creatine hydrochloride for 8 weeks improves reaction time in perimenopausal and menopausal women, as shown by a 1.2% change from baseline compared to a 6.6% change in the placebo group (p < 0.01). This suggests that medium-dose creatine hydrochloride may enhance cognitive processing speed during the menopausal transition.

Why this might work

Creatine hydrochloride supplementation increases the brain's creatine levels. Creatine acts as a backup energy source for brain cells, helping them produce energy faster during demanding tasks. This improved energy supply allows neurons to fire more efficiently, resulting in quicker reaction times.

Supported mechanismbased on 1 study

What the research says

1 study
  1. Study: The Effects of 8-Week Creatine Hydrochloride and Creatine Ethyl Ester Supplementation on Cognition, Clinical Outcomes, and Brain Creatine Levels in Perimenopausal and Menopausal Women (CONCRET-MENOPA): A Randomized Controlled Trial.

    The study gave women around menopause either a placebo or 1500 mg of creatine HCl daily for 8 weeks, and found that the creatine group had significantly faster reaction times than the placebo group, backing up the claim.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

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