The Claim

Six weeks of supplementation with 10 grams of creatine monohydrate and 2 grams of guanidinoacetic acid has no significant effect on working memory or spatial memory as measured by the Corsi Block test in healthy adults.

Source: Effects of 6 weeks of high-dose creatine monohydrate supplementation with or without guanidinoacetic acid on cognitive function

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
68score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

Quantitative
1 study reviewed
In plain English

Taking 10 grams of creatine monohydrate and 2 grams of guanidinoacetic acid daily for six weeks does not change performance on tests of working memory or spatial memory in healthy adults.

See the scientific wording

Six weeks of supplementation with 10 grams of creatine monohydrate and 2 grams of guanidinoacetic acid does not significantly improve working memory or spatial memory, as measured by the Corsi Block test, in healthy adults.

Why this might work

Taking creatine and guanidinoacetic acid raises the level of a high-energy molecule in brain cells, which helps neurons fire faster during tasks that require quick reactions. However, this energy boost does not make the brain better at remembering sequences of locations or holding information in mind for short periods.

Supported mechanismbased on 1 study

What the research says

1 study
  1. Study: Effects of 6 weeks of high-dose creatine monohydrate supplementation with or without guanidinoacetic acid on cognitive function

    The study gave people creatine and a related chemical for six weeks and tested their memory with a block-tapping game. Their memory didn’t get better, which matches the claim that this supplement combo doesn’t help memory.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

Fit Body Science verdict — we translate health claims into clear verdicts backed by peer-reviewed research.

Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.