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Strong Support

Taking creatine for a week might change genes in young men's muscles that help reshape the muscle structure, possibly because the muscle cells are holding more water.

60
Pro
0
Against

Evidence from Studies

Supporting (1)

60

Community contributions welcome

60

Global and targeted gene expression and protein content in skeletal muscle of young men following short-term creatine monohydrate supplementation.

Randomized Controlled Trial
Human
2008 Jan 17

The study gave young men the same creatine doses mentioned in the claim and found that genes involved in muscle structure changes were turned up, which supports the idea that creatine causes muscle cells to reorganize due to swelling.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Global and targeted gene expression and protein content in skeletal muscle of young men following short-term creatine monohydrate supplementation.

Score: 60
DOI: 10.1152/PHYSIOLGENOMICS.00157.2007

Similar Assertions

Taking creatine for a short time might turn on genes in young men's muscles that help fix DNA, possibly because the cells are reacting to the stress from holding more water.

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Taking creatine for just a week can turn on important muscle cell signals that help with growth and energy use in young, healthy guys.

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Taking creatine helps your muscle cells soak up more water, making them swell a bit—and this swelling tells your body to stop breaking down muscle as much.

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Taking creatine powder for about a week—first a lot, then a little—can boost the amount of creatine in your muscles by over 13%, which helps your muscles store more energy.

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Taking creatine for just a week can make young, healthy guys gain a little weight and look more muscular—even if they don’t work out, mostly because of water holding in their muscles.

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