The Claim

Short-term creatine monohydrate supplementation (20 g/day for 3 days followed by 5 g/day for 7 days) causes a 5.0-fold increase in sphingosine kinase-1 (SPHK1) mRNA expression in the skeletal muscle of healthy young men, indicating activation of a key regulator involved in myoblast differentiation and cell survival.

Source: Global and targeted gene expression and protein content in skeletal muscle of young men following short-term creatine monohydrate supplementation.

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
60score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

How it works
1 study reviewed
In plain English

Taking creatine for 10 days might turn on a gene in young men's muscles that helps muscle cells grow and stay alive.

See the scientific wording

Short-term creatine monohydrate supplementation (20 g/day × 3 days, then 5 g/day × 7 days) causes a 5.0-fold increase in sphingosine kinase-1 (SPHK1) mRNA expression in skeletal muscle of healthy young men, indicating activation of a key regulator of myoblast differentiation and cell survival.

What the research says

1 study

  1. Study: Global and targeted gene expression and protein content in skeletal muscle of young men following short-term creatine monohydrate supplementation.

    The study gave men the same creatine dose as in the claim and found that genes linked to muscle cell growth and survival, including one called SPHK1, increased up to 5 times, which matches the claim.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

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