The Claim

Short-term creatine monohydrate supplementation (20 g/day for 3 days followed by 5 g/day for 7 days) causes upregulation of genes involved in DNA replication and repair, including REPIN1 and TDP1, in the skeletal muscle of healthy young men, indicating enhanced genomic maintenance as a cellular response to creatine-induced osmotic stress.

Source: Global and targeted gene expression and protein content in skeletal muscle of young men following short-term creatine monohydrate supplementation.

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
60score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

How it works
1 study reviewed
In plain English

Taking creatine for a short time might turn on genes in young men's muscles that help fix DNA, possibly because the cells are reacting to the stress from holding more water.

See the scientific wording

Short-term creatine monohydrate supplementation (20 g/day × 3 days, then 5 g/day × 7 days) causes upregulation of genes involved in DNA replication and repair, such as REPIN1 and TDP1, in skeletal muscle of healthy young men, suggesting enhanced genomic maintenance as part of the cellular response to creatine-induced osmotic stress.

What the research says

1 study

  1. Study: Global and targeted gene expression and protein content in skeletal muscle of young men following short-term creatine monohydrate supplementation.

    The study gave men the same creatine dose as in the claim and found that genes involved in DNA repair and replication were turned up, which supports the idea that creatine helps cells maintain DNA by causing mild stress.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

Fit Body Science verdict — we translate health claims into clear verdicts backed by peer-reviewed research.

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