Creatine supplementation for up to 12 weeks does not produce statistically significant changes in total cholesterol, LDL cholesterol, HDL cholesterol, or triglyceride levels in adults, as demonstrated by a meta-analysis of 8 randomized placebo-controlled trials involving 111 participants in creatine groups and 106 in control groups.

When people take creatine, their body starts to use energy differently: it activates brown fat to burn more calories, helps liver cells fuse their energy factories (mitochondria) to burn more fat, and improves blood vessel health by reducing stress. But all these changes are small, and the body's normal control systems for cholesterol and triglycerides keep them balanced. So after up to 12 weeks of creatine, the amounts of good and bad cholesterol and fats in the blood stay the same.