The Claim
Six weeks of supplementation with creatine monohydrate at 10 g/day and guanidinoacetic acid at 2 g/day has no adverse effect on liver enzymes, electrolytes, blood lipids, or blood cell counts in healthy adults.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
Taking 10 grams of creatine monohydrate and 2 grams of guanidinoacetic acid daily for six weeks does not change liver enzyme levels, electrolyte balance, blood fat levels, or blood cell counts in healthy adults.
See the scientific wording
Six weeks of creatine monohydrate and guanidinoacetic acid supplementation at high doses (10 g/day and 2 g/day, respectively) does not adversely affect liver enzymes, electrolytes, blood lipids, or blood cell counts in healthy adults, supporting the short-term safety profile of these supplements.
The body naturally processes and clears excess creatine and guanidinoacetic acid without disrupting liver function, blood salt levels, cholesterol, or blood cell production because these compounds are handled by existing detox and excretion pathways that stay within safe limits.
What the research says
1 studyThis study gave healthy adults high doses of creatine and GAA for six weeks and checked their blood for signs of harm. Nothing bad happened — their liver, blood salts, cholesterol, and blood cells stayed normal, so it’s likely safe.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.