Taking 10 milligrams or more of melatonin every day for at least three months may help lower your body's overall inflammation levels. This happens because the supplement might block a specific cellular switch that normally triggers inflammatory chemicals like IL-6 and TNF-alpha.

Taking melatonin supplements appears to lower markers of inflammation in the body, such as CRP and IL-6. This reduction in inflammation might help protect the heart, especially for people who already have ongoing, low-level inflammation.

Animal studies suggest that humans might need 100 to 200 milligrams of melatonin daily to get its protective and anti-inflammatory benefits, which is much higher than the 2 to 10 milligrams usually tested in heart studies. This big difference in dosage might be why past heart research hasn't shown clear results.

Taking 10 mg of melatonin every day for six months does not appear to lower inflammation or help with sleep, anxiety, and depression in people with a specific type of heart failure. This suggests that melatonin is not very helpful for these particular symptoms in this patient group.

When you take melatonin pills, your body only absorbs about 15% of the dose into your bloodstream because most of it gets broken down before it can circulate. This means oral supplements deliver much less active melatonin to your system compared to an injection.

Taking melatonin supplements for a short time can help adults with insomnia fall asleep faster and feel like they're sleeping better. This effect is commonly seen at doses between 0.5 and 5 milligrams.