Taking L-citrulline pills for 10 days at a specific dose doesn’t seem to make healthy young adults feel sick—only a few people might get a little stomach upset.
Claim Language
Language Strength
probability
Uses probability language (may, likely, can)
The claim uses 'is well-tolerated' and 'reported in a minority'—these phrases suggest likelihood or observation rather than certainty. 'Well-tolerated' implies a favorable outcome based on observed experience, not absolute proof, and 'minor side effects reported in a minority' indicates frequency without claiming universality or causation.
Context Details
Domain
nutrition
Population
human
Subject
A 10-day L-citrulline supplementation at 100 mg/kg/day
Action
is well-tolerated
Target
in healthy young adults, with only minor gastrointestinal side effects reported in a minority of participants
Intervention Details
Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.
Evidence from Studies
Supporting (1)
The study gave people 100 mg of L-citrulline per kg of body weight for 10 days and didn’t find any serious problems — so it’s likely the supplement is safe and only causes mild stomach issues, if any, in a few people.