The Claim

L-citrulline supplementation at 100 mg/kg/day for 10 days has no significant effect on blood glucose or lactate concentrations at rest or during high-intensity cycling to exhaustion in healthy adults.

Source: Ergogenic effects of a 10-day L-citrulline supplementation on time to exhaustion and cardiorespiratory and metabolic responses in healthy individuals: a double-blind, randomised, placebo-controlled crossover trial

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
67score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

Description
1 study reviewed
In plain English

Taking 100 mg of L-citrulline per kilogram of body weight daily for 10 days does not change blood glucose or lactate levels during rest or intense cycling in healthy adults.

See the scientific wording

L-citrulline supplementation at 100 mg/kg/day for 10 days does not significantly affect blood glucose or lactate concentrations at rest or during high-intensity cycling to exhaustion in healthy adults, indicating no measurable impact on substrate metabolism under these conditions.

Why this might work

L-citrulline turns into arginine in the kidneys, which the body uses to make nitric oxide. Nitric oxide opens blood vessels to improve blood flow, but this does not change how the body uses sugar or produces lactic acid during intense exercise.

Supported mechanismbased on 1 study

What the research says

1 study
  1. Study: Ergogenic effects of a 10-day L-citrulline supplementation on time to exhaustion and cardiorespiratory and metabolic responses in healthy individuals: a double-blind, randomised, placebo-controlled crossover trial

    This study gave people L-citrulline for 10 days and had them bike hard until exhaustion. It found no change in their blood sugar or lactic acid levels, meaning the supplement didn’t affect how their body used fuel during exercise.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

Fit Body Science verdict — we translate health claims into clear verdicts backed by peer-reviewed research.

Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.