The Claim
In healthy, moderately active young adults, a 10-day supplementation with L-citrulline at a dosage of 100 mg/kg/day has no significant effect on cardiac output, oxygen uptake, blood pressure, lactate levels, or glucose responses during high-intensity cycling to exhaustion.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
Taking L-citrulline supplements for 10 days at 100 mg per kilogram of body weight does not change how the heart pumps blood, how much oxygen the body uses, blood pressure, lactate levels, or blood glucose during intense cycling to exhaustion in healthy young adults.
See the scientific wording
In healthy, moderately active young adults, a 10-day L-citrulline supplementation at 100 mg/kg/day does not significantly alter cardiac output, oxygen uptake, blood pressure, lactate, or glucose responses during high-intensity cycling to exhaustion.
L-citrulline is absorbed from the gut and converted into arginine in the kidneys. Arginine is used by blood vessel cells to make nitric oxide, which relaxes blood vessels and increases blood flow. This should improve oxygen delivery to muscles during exercise, but in healthy young adults, this pathway does not change heart output, oxygen use, blood pressure, lactate, or glucose levels during intense cycling.
What the research says
1 studyThis study gave people L-citrulline pills for 10 days and had them bike really hard. Their heart, lungs, blood pressure, and muscle chemicals didn't change compared to when they took a sugar pill — so the supplement didn't make a difference.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.