The Claim

Chronic supplementation with L-citrulline or citrulline malate increases post-exercise nitric oxide metabolite levels in resistance-trained men, with both supplements producing similar effects, indicating enhanced nitric oxide production as a potential mechanism for improved muscular endurance.

Source: Changes in resistance training performance, rating of perceived exertion, and blood biomarkers after six weeks of supplementation with L-citrulline vs. L-citrulline DL-malate in resistance-trained men: a double-blind placebo-controlled trial

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
59score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

How it works
1 study reviewed
In plain English

Taking L-citrulline or citrulline malate regularly may raise levels of nitric oxide metabolites after exercise in men who train with weights, and both forms appear to have comparable effects.

See the scientific wording

Chronic supplementation with L-citrulline or citrulline malate increases post-exercise nitric oxide metabolite levels in resistance-trained men, with both supplements showing similar effects, suggesting enhanced nitric oxide production as a potential mechanism for improved muscular endurance.

What the research says

1 study

  1. Study: Changes in resistance training performance, rating of perceived exertion, and blood biomarkers after six weeks of supplementation with L-citrulline vs. L-citrulline DL-malate in resistance-trained men: a double-blind placebo-controlled trial

    This study found that taking either L-citrulline or citrulline malate for six weeks helped resistance-trained men produce more nitric oxide after workouts, and both supplements worked about the same. More nitric oxide may help muscles work longer during exercise.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

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