Taking melatonin for sleep over a long period might slightly increase your chance of developing heart failure compared to not taking it. This small but noticeable increase in risk means doctors should keep an eye on heart health when prescribing it for insomnia.

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Pro

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Against

Evidence from Studies

Supporting (1)

59

Community contributions welcome

59

Abstract 4371606: Effect of Long-term Melatonin Supplementation on Incidence of Heart Failure in Patients with Insomnia

Cohort Study

Human

This large study found that adults with insomnia who took melatonin long-term were nearly twice as likely to develop heart failure over five years compared to those who did not take it. The results suggest that long-term melatonin use might carry heart risks that doctors should consider.

Contradicting (0)

0

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No contradicting evidence found

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According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Abstract 4371606: Effect of Long-term Melatonin Supplementation on Incidence of Heart Failure in Patients with Insomnia

Score: 59

DOI: 10.1161/circ.152.suppl_3.4371606

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