Taking melatonin supplements appears to lower markers of inflammation in the body, such as CRP and IL-6. This reduction in inflammation might help protect the heart, especially for people who already have ongoing, low-level inflammation.

Our current analysis shows that melatonin appears to lower inflammation and may help protect heart cells. The evidence we have reviewed leans toward melatonin reducing inflammatory markers in the body, such as CRP and IL-6, which are proteins that signal swelling and immune activity [1]. This drop in inflammation might support heart health, particularly for individuals dealing with constant, low-level inflammation [1]. What we have found so far suggests that melatonin also shields the heart and blood vessels from damage. It does this by calming inflammatory responses and neutralizing harmful molecules that can stress tissues [2]. Our review indicates that melatonin works by activating the body’s built-in defense mechanisms and safeguarding the power sources inside heart cells [2]. 46 studies support, 0 studies refute. The evidence we have reviewed leans toward melatonin playing a supportive role in heart and blood vessel health through these anti-inflammatory pathways. We want to be clear that this is a partial view based on our current analysis, and the full picture may shift as more research becomes available. We do not claim to have all the answers, and the data we have looked at so far simply points to these potential connections. If you are considering melatonin for heart or inflammation support, talk to a healthcare provider about whether it fits your situation. Starting with a low dose and monitoring how you feel can help you see if it aligns with your health goals.