The Claim
Melatonin supplementation is associated with reduced systemic inflammation, as indicated by decreased levels of C-reactive protein, interleukin-6, and tumor necrosis factor-alpha, which may contribute to cardioprotective effects in populations with chronic low-grade inflammation.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
Taking melatonin supplements appears to lower markers of inflammation in the body, such as CRP and IL-6. This reduction in inflammation might help protect the heart, especially for people who already have ongoing, low-level inflammation.
See the scientific wording
Melatonin supplementation is associated with reduced systemic inflammation, evidenced by significant decreases in C-reactive protein (WMD: -0.59 mg/L), interleukin-6 (WMD: -6.43 pg/mL), and tumor necrosis factor-alpha (WMD: -1.61 pg/mL). These anti-inflammatory effects may contribute to melatonin's broader cardioprotective profile, particularly in populations with chronic low-grade inflammation.
What the research says
1 studyMeta-analysis of 21-11 RCTs for respective markers showed statistically significant pooled reductions compared to placebo. The consistent directional changes across acute-phase proteins and cytokines support a broad anti-inflammatory mechanism.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.