Taking melatonin supplements might slightly lower your top blood pressure number by about 2 points. However, how much it actually helps depends on your starting blood pressure and other personal health factors, so the real-world benefit isn't the same for everyone.

45

Pro

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Evidence from Studies

Supporting (1)

45

Community contributions welcome

45

Comprehensive Effects of Melatonin Supplementation on Cardiometabolic Risk Factors: A Systematic Review and Dose–Response Meta-Analysis

Systematic Review With Meta-Analysis

Human

2025 Dec 31

The study confirms that taking melatonin supplements slightly lowers systolic blood pressure by about 2.34 mmHg on average. This matches the claim exactly, showing a small but consistent blood pressure-lowering effect.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Comprehensive Effects of Melatonin Supplementation on Cardiometabolic Risk Factors: A Systematic Review and Dose–Response Meta-Analysis

Score: 45

DOI: 10.3390/nu18010134

Science Topic

Does melatonin supplementation lower systolic blood pressure?

Supported

What we've found so far suggests that melatonin supplementation might lower systolic blood pressure. Systolic blood pressure is the top number in a blood pressure reading. Our current analysis indicates that the evidence leans toward a small reduction in this number. We analyzed the available research and found that taking melatonin supplements could lower the top blood pressure number by about 2 points [1]. We found that 45.0 studies support, 0 studies refute this observation. We reviewed these assertions to build our understanding. Our analysis shows that the potential benefit is not the same for everyone. The actual effect depends on your starting blood pressure level. It also depends on other personal health factors. This means the real-world benefit varies from person to person. We emphasize that this is our current analysis. The evidence we've reviewed suggests a trend, but individual results may differ. We continue to monitor new data as it becomes available. If you are thinking about using melatonin, remember that the effect might be small. The impact depends on your specific health situation. You should talk to a healthcare provider about whether melatonin is right for you. They can help you understand how it might affect your blood pressure based on your personal details.

2 items of evidenceView full answer

Similar Assertions

Taking melatonin supplements might help lower high blood pressure at night and improve overall blood pressure readings in people with heart conditions. This effect seems to happen because melatonin could help relax blood vessels and calm the nervous system.

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Taking melatonin supplements may lower your blood pressure, blood sugar, and bad cholesterol, while also reducing inflammation and boosting your body's natural antioxidants.

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Taking melatonin supplements can help lower high blood pressure, especially at night, by improving blood vessel function and balancing the body's natural sleep-wake rhythms. This is particularly helpful for people who don't normally see their blood pressure drop at night or those with metabolic syndrome, potentially protecting their heart and blood vessels over the long term.

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Taking melatonin supplements appears to help heart failure patients feel better and lower stress markers in their heart, but it doesn't reliably improve the heart's pumping strength.

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Taking melatonin supplements seems to lower fasting blood sugar levels in adults by about 11.6 mg/dL on average. This effect is strongest in people whose blood sugar is already normal or only slightly high, but researchers caution that the current evidence isn't strong enough to rely on melatonin as a main treatment for blood sugar control.

45

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