Taking nitrate supplements helps protect blood vessels from damage caused by temporary lack of blood flow followed by restoration of blood flow.
Scientific Claim
Inorganic nitrate supplementation prevents ischemia-reperfusion-induced endothelial dysfunction in healthy adults, as demonstrated by preserved flow-mediated dilation after nitrate administration compared to control.
Original Statement
“In addition to the reduction in BP, nitrate capsules prevented IR-induced endothelial dysfunction (Figure S4). Moreover, this effect was not evident after chloride capsule ingestion.”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
definitive
Can make definitive causal claims
Assessment Explanation
This is a controlled study with direct measurement of endothelial function showing that nitrate supplementation prevented dysfunction that occurred with control. The language 'prevents' appropriately describes the observed protective effect.
Evidence from Studies
Supporting (1)
Inorganic Nitrate Supplementation Lowers Blood Pressure in Humans: Role for Nitrite-Derived NO