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Inorganic Nitrate Supplementation Lowers Blood Pressure in Humans: Role for Nitrite-Derived NO
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Your body turns nitrate from food into nitrite, which helps relax blood vessels. This study tested if adding extra nitrate lowers blood pressure.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 550 / 90
Evidence Score
Participants are randomly assigned to treatment or control groups, minimizing bias. Considered the gold standard for testing whether an intervention causes an effect.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Your body turns nitrate from food into nitrite, which helps relax blood vessels. This study tested if adding extra nitrate lowers blood pressure.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 550 / 90
Evidence Score
Participants are randomly assigned to treatment or control groups, minimizing bias. Considered the gold standard for testing whether an intervention causes an effect.
Publication
Authors
Kapil V, Milsom AB, Okorie M, Maleki-Toyserkani S, Akram F, Rehman F, Arghandawi S, Pearl V, Benjamin N, Loukogeorgakis S, Macallister R, Hobbs AJ, Webb AJ, Ahluwalia A
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Claims (10)
Bacteria in the mouth help regulate blood pressure by converting nitrate to nitrite, which is part of the body's natural blood pressure control system.
Taking nitrate supplements lowers blood pressure, and the more you take, the more your blood pressure goes down. The biggest drop was about 9 mm Hg for systolic and 6 mm Hg for diastolic blood pressure.
When nitrite levels in the blood go up after taking nitrate supplements, blood pressure tends to go down more. The higher the nitrite increase, the bigger the blood pressure drop.
People with higher blood pressure to start with tend to see bigger drops in blood pressure when they take nitrate supplements.
Taking nitrate supplements increases cGMP in the blood, which is a sign that nitric oxide is being produced and working in the body.