Older adults with mild to moderate Alzheimer’s who took statins for 18 months didn’t have more liver problems or falls than those who didn’t — the study found no real difference.

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Evidence from Studies

Supporting (1)

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What is the impact of ongoing statin use on cognitive decline and dementia progression in older adults with mild-moderate Alzheimer disease?

Cohort Study

Human

2023

Contradicting (0)

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No contradicting evidence found

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According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

What is the impact of ongoing statin use on cognitive decline and dementia progression in older adults with mild-moderate Alzheimer disease?

Score: 58

DOI: 10.1371/journal.pone.0285529

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Taking statins might help lower the chance of getting Alzheimer’s disease — studies show people who use them have about an 18% lower risk.

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Taking statins might help lower the chance of getting Alzheimer’s disease — studies show people on statins had about an 18% lower risk.

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For older adults with mild to moderate Alzheimer's, taking statins for 18 months didn’t seem to cause more health problems, hospital stays, or serious issues — and while they did visit their doctor more at first, that link went away when researchers accounted for other factors.

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For older people with mild to moderate Alzheimer's, taking statins for 18 months doesn't clearly slow down how fast their symptoms get worse — there's a hint it might help a little, but it's not strong enough to be sure.

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Taking statins doesn't seem to change how well people with mild to moderate Alzheimer's can handle everyday tasks like dressing or cooking over 18 months.

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