If you're an obese adult, taking a daily injection of liraglutide for 5 weeks might help you lose about 2.7% more weight than if you took a fake pill, and it could also lower your blood sugar, bad...

If someone is obese and takes a weight-loss drug called liraglutide for 5 weeks, their brain doesn’t react differently to pictures of food — at least not if we don’t factor in how much weight they lost.

In adults with obesity and prediabetes, losing weight through calorie reduction maintains muscle mass, but taking 1.8 mg of liraglutide daily causes muscle mass to decrease.

In adults with obesity and prediabetes, taking 1.8 mg of liraglutide daily increases feelings of fullness and reduces self-reported desire to eat later, but does not lower the actual amount of calories consumed compared to dieting alone.

In adults with obesity and prediabetes, a 14-week diet creating a 390 kcal daily deficit leads to more weight loss and a greater improvement in body fat-to-muscle ratio than daily 1.8 mg liraglutide.

In people with obesity and prediabetes, the drug liraglutide lowers blood glucose levels after eating and in the fasted state within two weeks, even without weight loss, and these effects are not seen with other approaches like sitagliptin or dieting alone.