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Back to Study: Longer‐term liraglutide administration at the high...
causal
Analysis v1
Strong Support

If you're an obese adult, taking a daily injection of liraglutide for 5 weeks might help you lose about 2.7% more weight than if you took a fake pill, and it could also lower your blood sugar, bad cholesterol, and waist size — plus you might naturally eat less fat and fewer calories.

66
Pro
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Evidence from Studies

Supporting (1)

66

Community contributions welcome

66

Longer‐term liraglutide administration at the highest dose approved for obesity increases reward‐related orbitofrontal cortex activation in response to food cues: Implications for plateauing weight loss in response to anti‐obesity therapies

Randomized Controlled Trial
Human
2019 Nov

The study gave obese adults liraglutide for 5 weeks and found they lost 2.7% more weight than those on placebo, with better blood sugar and cholesterol, just like the claim says.

Contradicting (0)

0

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Longer‐term liraglutide administration at the highest dose approved for obesity increases reward‐related orbitofrontal cortex activation in response to food cues: Implications for plateauing weight loss in response to anti‐obesity therapies

Score: 66
DOI: 10.1111/dom.13827

Similar Assertions

If someone is obese and takes a weight-loss drug called liraglutide for 5 weeks, their brain doesn’t react differently to pictures of food — at least not if we don’t factor in how much weight they lost.

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82%

Taking the drug liraglutide at 3.0 mg might help people with obesity better control their impulses, like stopping themselves from doing something quickly, even if their reaction speed didn't clearly improve.

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66
72%

When people take liraglutide for weight loss, their brain's 'decision-making' area might become more active as a way to push back against further weight loss — which could be why the pounds stop dropping after a while.

66
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71%