The Claim
Triiodothyronine increases mRNA expression of multiple subunits of the 26S proteasome and ubiquitin-conjugating enzymes in human skeletal muscle, indicating enhanced capacity for ATP-dependent protein degradation.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
Triiodothyronine raises the levels of messenger RNA for proteins involved in breaking down other proteins in human skeletal muscle, resulting in a greater ability to degrade proteins using energy.
See the scientific wording
Triiodothyronine increases mRNA expression of multiple subunits of the 26S proteasome and ubiquitin-conjugating enzymes in human skeletal muscle, indicating enhanced capacity for ATP-dependent protein degradation.
Triiodothyronine enters muscle cells and binds to receptors in the nucleus, which turns on genes that make more parts of the protein-breaking machine. This machine uses tags called ubiquitin to mark unwanted proteins, then chops them into pieces using energy from ATP. More machine parts mean more proteins get broken down.
What the research says
1 studyStudy: In vivo regulation of human skeletal muscle gene expression by thyroid hormone.
This study gave people a thyroid hormone and found that their muscles started making more of the genetic instructions needed to break down proteins — exactly what the claim says.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.