The Claim
High-dose resveratrol supplementation (≥500 mg/day) in older adults is associated with increased levels of biomarkers of cardiovascular disease risk, including LDL cholesterol and inflammatory markers.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
Taking 500 mg or more of resveratrol daily in older adults is linked to higher levels of LDL cholesterol and inflammatory markers, which are indicators of increased cardiovascular disease risk.
See the scientific wording
High-dose resveratrol supplementation (≥500 mg/day) in older adults may increase biomarkers of cardiovascular disease risk, such as LDL cholesterol or inflammatory markers, suggesting potential harm at elevated doses despite overall safety.
High doses of resveratrol overload the liver's ability to process fats, causing it to produce more bad cholesterol and trigger inflammation in the bloodstream.
What the research says
1 studyStudy: Effects and safety of resveratrol supplementation in older adults: A comprehensive systematic review
Taking very high doses of resveratrol (500 mg or more) may raise blood markers linked to heart disease risk, even though it doesn’t cause obvious side effects — and this study found exactly that in older adults.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.