TAS1R3 helps muscle cells take up glucose even when insulin is not present, suggesting it plays a role in baseline glucose metabolism beyond just insulin response.
Evidence from Studies
No evidence studies found yet.
What Would Prove This
Per GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this claim, ordered from strongest to weakest.
Whether TAS1R3 consistently contributes to basal glucose uptake across skeletal muscle models and whether this effect is independent of insulin.
A systematic review and meta-analysis of all studies measuring basal glucose uptake in skeletal muscle cells following TAS1R3 inhibition or knockout, across human, rodent, and cell line models, with standardized assays and reporting of insulin-independent effects.
Whether systemic TAS1R3 inhibition reduces basal glucose disposal in humans during fasting conditions.
A double-blind, crossover RCT in 30 healthy adults, comparing intravenous lactisole versus saline during a 12-hour fast, with whole-body glucose turnover measured by stable isotope tracer methodology and muscle biopsies for TAS1R3 expression and Rac1 activation.
Whether individuals with lower TAS1R3 expression exhibit reduced basal glucose uptake in muscle during fasting.
A prospective cohort of 100 adults with varying insulin sensitivity, measuring fasting muscle glucose uptake via microdialysis and TAS1R3 expression via biopsy, with adjustment for BMI, age, and fasting insulin.
Whether basal glucose uptake is lower in T2D-derived myotubes compared to non-diabetic myotubes, and whether this correlates with TAS1R3 levels.
A case-control study comparing basal glucose uptake in LHCN-M2 myotubes derived from 25 T2D and 25 non-diabetic donors, with TAS1R3 expression quantified and uptake measured under identical fasting conditions.
Whether TAS1R3 inhibition reduces basal glucose uptake in human myotubes in a single experimental setting.
A cross-sectional experiment measuring basal glucose uptake in LHCN-M2 myotubes after 1-hour exposure to lactisole or vehicle, without insulin stimulation, using [3H]2-DG assay and TAS1R3 expression confirmed by qPCR.