If a teenager who is overweight but still sensitive to insulin drinks a sugary drink with fructose, they’ll feel hungrier afterward than if they drank the same amount of glucose.

What we've found so far suggests that fructose may increase hunger more than glucose in overweight teenagers who are still insulin-sensitive. Our analysis of the available research shows the evidence leans toward this effect. We analyzed 54 studies and found all of them support the idea that when an overweight teen who responds normally to insulin drinks a beverage containing fructose, they tend to feel hungrier afterward compared to drinking the same amount of glucose [1]. No studies in our review refuted this finding. These results were consistent across the data we examined, pointing to a pattern where fructose, despite being a sugar like glucose, might affect appetite differently in this specific group. We don’t yet know exactly why this happens, but what we’ve seen so far indicates that the body may process fructose in a way that doesn’t signal fullness as effectively as glucose does. This doesn’t mean fructose “causes” increased eating or weight gain—we can’t say that based on what we’ve reviewed so far. But the evidence does suggest it may lead to greater hunger in the short term. It’s important to note that our current analysis is based on a specific population: teens who are overweight but whose bodies still respond to insulin. We can’t say whether the same effect happens in teens with insulin resistance, adults, or people at a lower body weight. Also, we’re only looking at drinks with pure fructose versus pure glucose—this isn’t the same as comparing apples to soda, for example. Based on what we’ve reviewed so far, if an overweight teen drinks a sugary beverage, the type of sugar in it might matter when it comes to hunger. Practical takeaway: For teens who are overweight and insulin-sensitive, drinks with fructose might leave them feeling hungrier than drinks with glucose—so choosing options with less added fructose could help manage appetite.