Why Fructose Might Make Some Kids Hungrier
Blunted suppression of acyl‐ghrelin in response to fructose ingestion in obese adolescents: The role of insulin resistance
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
Fasting acyl-ghrelin was lowest in insulin-resistant obese teens, not highest.
Most people assume higher hunger hormone = more hunger, but here, the group with the *lowest* baseline ghrelin (OIR) had the worst suppression after sugar—suggesting hormone resistance, not levels, is the real problem.
Practical Takeaways
Limit fructose-heavy drinks (like soda and juice) in teens, especially if they’re overweight or have prediabetes signs.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
Fasting acyl-ghrelin was lowest in insulin-resistant obese teens, not highest.
Most people assume higher hunger hormone = more hunger, but here, the group with the *lowest* baseline ghrelin (OIR) had the worst suppression after sugar—suggesting hormone resistance, not levels, is the real problem.
Practical Takeaways
Limit fructose-heavy drinks (like soda and juice) in teens, especially if they’re overweight or have prediabetes signs.
Publication
Journal
Obesity
Year
2015
Authors
M. V. Van Name, C. Giannini, N. Santoro, Ania M Jastreboff, J. Kubat, Fangyong Li, R. Kursawe, M. Savoye, Elvira Duran, J. Dziura, R. Sinha, R. Sherwin, G. Cline, S. Caprio
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Claims (7)
Fructose in your diet doesn't make you feel full the way other sugars might because it doesn't trigger the right hunger hormones, so you might end up eating more than you need.
When obese teens drink a sugary drink with fructose, their hunger hormone doesn't go down like it does in lean teens — meaning their bodies don't signal fullness as well.
If a teenager is obese and their body doesn't respond well to insulin, drinking something with a lot of fructose (like sugary soda) won't quiet down the hunger hormone ghrelin as much as it would in an obese teen whose body still responds normally to insulin.
When obese teens have trouble responding to insulin, their hunger hormone doesn't go down as much after drinking a sugary drink compared to lean teens. But if they're obese and still respond well to insulin, their hormone response is just like that of lean teens.
If a teenager who is overweight but still sensitive to insulin drinks a sugary drink with fructose, they’ll feel hungrier afterward than if they drank the same amount of glucose.