In pigs under anesthesia, certain diabetes-related peptides like exendin-4 are removed from the body only by the kidneys, while others like GLP-1 are cleared by both the kidneys and other body tissues — showing they leave the body in different ways.

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Evidence from Studies

Supporting (1)

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Community contributions welcome

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The C-terminal extension of exendin-4 provides additional metabolic stability when added to GLP-1, while there is minimal effect of truncating exendin-4 in anaesthetized pigs.

Cross-Sectional Study

Animal

2013 Feb 10

The study shows that exendin-4 and its shortened version leave the body only through the kidneys, while GLP-1 and a modified version are removed by both kidneys and other tissues, just like the claim says.

Contradicting (0)

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

The C-terminal extension of exendin-4 provides additional metabolic stability when added to GLP-1, while there is minimal effect of truncating exendin-4 in anaesthetized pigs.

Score: 14

DOI: 10.1016/j.regpep.2012.12.012

Similar Assertions

When scientists studied a lab-made version of a hormone in rat kidney mixtures, they found it breaks apart at two specific spots, creating two smaller pieces as the first step in its breakdown.

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Cutting off the end of a hormone called exendin-4 doesn’t make it break down faster in anesthetized pigs, so that part probably doesn’t matter much for how long the hormone lasts in their bodies.

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In rats, the body breaks down a substance called exendin-4 differently in the kidneys and liver — the kidneys chop it up in several places early on, while the liver makes one main cut first and then trims the ends.

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In pigs under anesthesia, adding a small piece from a lizard hormone to a blood sugar hormone makes it last much longer in the body.

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