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Claim
Strong Support
mechanistic
Analysis v3

In pigs under anesthesia, certain diabetes-related peptides like exendin-4 are removed from the body only by the kidneys, while others like GLP-1 are cleared by both the kidneys and other body...

14
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Against

Evidence from Studies

Supporting (1)

14

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14

The C-terminal extension of exendin-4 provides additional metabolic stability when added to GLP-1, while there is minimal effect of truncating exendin-4 in anaesthetized pigs.

Cross-Sectional Study
Animal
2013 Feb 10

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Source Study

The C-terminal extension of exendin-4 provides additional metabolic stability when added to GLP-1, while there is minimal effect of truncating exendin-4 in anaesthetized pigs.

Score: 14
DOI: 10.1016/j.regpep.2012.12.012

Similar Assertions

When scientists studied a lab-made version of a hormone in rat kidney mixtures, they found it breaks apart at two specific spots, creating two smaller pieces as the first step in its breakdown.

8
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Cutting off the end of a hormone called exendin-4 doesn’t make it break down faster in anesthetized pigs, so that part probably doesn’t matter much for how long the hormone lasts in their bodies.

14
0
71%

In rats, the body breaks down a substance called exendin-4 differently in the kidneys and liver — the kidneys chop it up in several places early on, while the liver makes one main cut first and then trims the ends.

8
0
71%

In pigs under anesthesia, adding a small piece from a lizard hormone to a blood sugar hormone makes it last much longer in the body.

14
0
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