The Claim

Increased activation of the orbitofrontal cortex during liraglutide treatment, independent of weight loss, may reflect a counter-regulatory neural response that contributes to the plateauing of weight loss commonly observed with anti-obesity medications.

Source: Longer‐term liraglutide administration at the highest dose approved for obesity increases reward‐related orbitofrontal cortex activation in response to food cues: Implications for plateauing weight loss in response to anti‐obesity therapies

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
66score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

How it works
1 study reviewed
In plain English

When people take liraglutide for weight loss, their brain's 'decision-making' area might become more active as a way to push back against further weight loss — which could be why the pounds stop dropping after a while.

See the scientific wording

The increase in orbitofrontal cortex activation during liraglutide treatment, when adjusted for weight loss, may represent a counter-regulatory brain response that contributes to the eventual plateauing of weight loss observed with anti-obesity medications.

What the research says

1 study

  1. Study: Longer‐term liraglutide administration at the highest dose approved for obesity increases reward‐related orbitofrontal cortex activation in response to food cues: Implications for plateauing weight loss in response to anti‐obesity therapies

    The study shows that when people take liraglutide, their brain’s reward area becomes more active in response to food after accounting for weight loss, which might explain why weight loss slows down over time.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

Fit Body Science verdict — we translate health claims into clear verdicts backed by peer-reviewed research.

Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.