The cells that make both IL-17 and IFN-γ actually went down after stress — meaning the IL-17 causing damage probably came from cells that were already making it, not new ones being created.

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Th17 cells and IL-17 are involved in the disruption of vulnerable plaques triggered by short-term combination stimulation in apolipoprotein E-knockout mice

Cohort Study

Animal

2013 Jul

The study says IL-17 and Th17 cells are involved in plaque rupture, but it never looked at the specific type of immune cell the claim is about, so we can't tell if the claim is right or wrong.

Source Study

Th17 cells and IL-17 are involved in the disruption of vulnerable plaques triggered by short-term combination stimulation in apolipoprotein E-knockout mice

Score: 17

DOI: 10.1038/cmi.2013.4

Similar Assertions

When the plaques burst in the mice, a chemical called IL-17 showed up in high amounts in their blood and right where the plaque broke — like a warning signal at the scene of the damage.

74%

When mice with fatty arteries were stressed, the number of a specific type of immune cell called Th17 went up dramatically — but another type, Th1, stayed the same, suggesting Th17 might be special in causing artery damage.

73%