When the plaques burst in the mice, a chemical called IL-17 showed up in high amounts in their blood and right where the plaque broke — like a warning signal at the scene of the damage.
Scientific Claim
In apolipoprotein E-knockout mice with ruptured plaques, serum interleukin-17 (IL-17) levels are significantly elevated compared to controls (p<0.001), and IL-17 protein is detected in the vicinity of ruptured plaque regions, suggesting a local and systemic immune response tied to plaque disruption.
Original Statement
“At 14 weeks, the level of IL-17 was higher in the treatment group than in the control groups after collar placement, with no difference at 6 weeks... IL-17 expression was observed in the region around the ruptured plaques.”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study uses precise measurements (ELISA, immunohistochemistry) and avoids causal language. The association between IL-17 and rupture is clearly presented within the mouse model.
Evidence from Studies
Supporting (1)
Scientists found that when plaques in mice burst, there was a lot more IL-17—a protein that triggers inflammation—both in the blood and right around the burst area, showing the immune system is actively involved in making plaques unstable.