The collagen scaffold by itself didn't help heal the knee ligament in pigs—other biological factors like platelets might be needed.
Scientific Claim
In Yucatan minipigs, collagen scaffold alone was insufficient to enhance ACL healing, indicating that additional biologic factors may be required for effective repair.
Original Statement
“The results of this study show that the use of an atelocollagen scaffold alone to enhance primary suture repair of the ACL was not effective. [...] Based on this collection of results, one might hypothesize that platelets or MSCs add a biologic stimulus, while the collagen scaffold provides the structural support, and both are required to stimulate ligament or tendon healing.”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
probability
Can suggest probability/likelihood
Assessment Explanation
The claim uses 'may be required' to reflect the study's hypothesis-based conclusion, avoiding definitive causal language for animal data.
Evidence from Studies
Supporting (1)
Collagen scaffold supplementation does not improve the functional properties of the repaired anterior cruciate ligament