The drug lowered the activity of enzymes that break down the structural fibers in plaques, which may help keep plaques from rupturing.

0

Pro

14

Against

Evidence from Studies

Supporting (0)

0

Community contributions welcome

No supporting evidence found

Contradicting (1)

14

Community contributions welcome

14

Atorvastatin Improves Plaque Stability in ApoE-Knockout Mice by Regulating Chemokines and Chemokine Receptors

Cohort Study

Animal

2014

The study found that the drug made certain enzymes (MMPs) that break down plaque material go up, not down — the opposite of what the claim says.

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Atorvastatin Improves Plaque Stability in ApoE-Knockout Mice by Regulating Chemokines and Chemokine Receptors

Score: 14

DOI: 10.1371/journal.pone.0097009

Similar Assertions

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14

0

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15

0

75%