The drug rapamycin has been proven to help mice and dogs live longer and healthier when given during middle to late life, making it the most reliable drug for fighting aging in animal studies.
Evidence from Studies
No evidence studies found yet.
What Would Prove This
Per GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this claim, ordered from strongest to weakest.
Synthesize all preclinical evidence across species to establish consistency and magnitude of rapamycin's effects on lifespan
A systematic review and meta-analysis of all controlled rapamycin lifespan studies in mammalian models, stratifying by species, dose, treatment timing, and duration, with quality assessment of study designs
Establish whether rapamycin causes lifespan extension in humans
A double-blind RCT with 1000+ adults aged 65-80, randomized to low-dose rapamycin (1-5mg weekly) vs placebo for 5-10 years, with primary outcome of all-cause mortality and secondary outcomes of age-related disease incidence
Establish association between rapamycin use and mortality in humans
Prospective cohort of 10,000 adults aged 60+ using rapamycin for immunosuppression vs matched controls not using rapamycin, following for 20+ years for mortality and age-related disease outcomes
Synthesize mechanistic understanding and guide future research directions
N/A - this study type is what the current evidence represents