A drug called RGX202 sticks to the same spot on a protein that carries creatine in the body, kind of like two keys trying to fit in the same lock — so creatine can't get in, and its movement gets blocked.

Creatine sticks to a special spot in a human protein using specific handholds, kind of like a key fitting into a lock, with certain parts of the protein helping hold it in place using molecular Velcro and tiny magnets.

Imagine creatine needs to get into cells through a special door that only opens one way. When creatine teams up with salt ions (sodium and chloride), the door becomes much less likely to let creatine slip back out, so it keeps moving in even when there’s already a lot of creatine inside the cell.

When creatine teams up with salt particles (sodium and chloride), it becomes much less likely to stick around inside the cell, so it can keep getting pulled in from outside—even when there’s already a lot of creatine inside.

Your body has a special door called CRT-1 that lets creatine into muscle cells by using salt particles (sodium and chloride) as helpers — it doesn’t need potassium to do this, and it can pull creatine in even when there’s already a lot inside the cell.

Creatine gets into human cells in two ways: one is like a precise lock-and-key system that works well at low levels, and the other is a more general process that kicks in when there's a lot of creatine around.