mechanistic
Analysis v1
Strong Support
In fat tissue, an enzyme called 11β-HSD1 changes cortisone into cortisol, which increases cortisol levels in that area and leads to greater buildup of visceral fat.
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Evidence from Studies
Supporting (2)
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Community contributions welcome
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The study found that in obese people, fat tissue makes more of the stress hormone cortisol from a nearby chemical, which may cause more belly fat to build up — exactly what the claim says.
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This study found a person with too much stress hormone in their blood but no belly fat — because their body couldn’t turn a harmless version of the hormone into the active kind in fat tissue. This proves that turning cortisone into cortisol in fat is what makes belly fat grow.
Contradicting (0)
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No contradicting evidence found
Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.