A flu-like vaccine called X-31ca helps mice fight off a common cold virus called RSV, but only for a few days—after about two weeks, it doesn’t work at all.

Pro

Against

Evidence from Studies

Supporting (1)

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Non-specific Effect of Vaccines: Immediate Protection against Respiratory Syncytial Virus Infection by a Live Attenuated Influenza Vaccine

Randomized Controlled Trial

Animal

2018

Contradicting (0)

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Non-specific Effect of Vaccines: Immediate Protection against Respiratory Syncytial Virus Infection by a Live Attenuated Influenza Vaccine

Score: 12

DOI: 10.3389/fmicb.2018.00083

Similar Assertions

When scientists gave mice a special flu-like vaccine called X-31ca, it helped them fight off a common cold virus — but only if their immune system had two specific sensors (TLR3 and TLR7). When those sensors were turned off, the vaccine stopped working, meaning those sensors are essential for the quick, general protection it provides.

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