In human fat tissue under the skin, the activity of certain genes involved in fat development does not change based on a person's body weight or fat levels, suggesting that how fat tissue is organized during development is separate from how much fat is present.

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Evidence from Studies

Supporting (1)

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Distinct developmental signatures of human abdominal and gluteal subcutaneous adipose tissue depots.

Cross-Sectional Study

Human & In Vitro

2013 Jan

Scientists found that the genes that tell fat where to grow on your body (like belly vs. hips) are set early in life and don’t change just because you gain or lose weight. So your fat distribution is more like a blueprint than a result of how much you weigh.

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Source Study

Distinct developmental signatures of human abdominal and gluteal subcutaneous adipose tissue depots.

Score: 41

DOI: 10.1210/jc.2012-2953

Similar Assertions

Fat tissue under the skin in the abdomen and buttocks has different patterns of gene activity, with certain genes involved in body development being less active in buttock fat than in abdominal fat, regardless of body weight.

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Fat cells from the abdomen and buttocks show different patterns of HOX gene activity, and these differences remain even when the cells are grown in a lab dish, suggesting the patterns are inherent to the cells themselves and were set early in development, not by their current location.

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The HOXC13 gene is active only in fat tissue under the skin of the buttocks in both men and women, and not in abdominal fat tissue, which may indicate it helps define the distinct metabolic behavior of gluteal fat.

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