In mice, the genes that affect how long they live work differently in males and females — many of the gene interactions are totally separate between the sexes.

18

Pro

0

Against

Evidence from Studies

Supporting (1)

18

Community contributions welcome

18

Genetic Modulation of Lifespan: Dynamic Effects, Sex Differences, and Body Weight Trade-offs

Cohort Study

Animal

The study found that different genes affect how long male and female mice live, and most of the gene interactions that influence lifespan are completely different between the sexes, which supports the claim.

Contradicting (0)

0

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Genetic Modulation of Lifespan: Dynamic Effects, Sex Differences, and Body Weight Trade-offs

Score: 18

DOI: 10.1101/2025.04.27.649857

Similar Assertions

In mice with different genes, scientists found 29 specific gene spots that affect how long they live — but these genes act differently depending on whether the mouse is young or old, and whether it's male or female. Some genes only matter at certain life stages, and some even switch from helping to hurting (or vice versa) as the mouse ages.

18

0

85%

Some genes linked to living longer depend on whether they come from your mom or dad — different sets of genes seem to help men and women live longer.

49

0

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In mice, certain genes seem to link being heavier early in life to a shorter life, especially in males — but being heavier later in life is actually linked to living longer, showing that the effect of weight on lifespan changes with age and sex.

18

0

72%