A specific genetic change called A554V messes up a natural 'brake' on a protein that copies DNA patterns, making it harder for two parts of that protein to stick together properly.

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Pro

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Against

Evidence from Studies

Supporting (1)

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Community contributions welcome

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Disease-Associated Mutation A554V Disrupts Normal Autoinhibition of DNMT1

Cross-Sectional Study

In Vitro

2023 Sep

Scientists tested the A554V mutation and found it breaks DNMT1's built-in brake system, making the enzyme hyperactive by weakening the connection between two protein domains - exactly what the claim describes.

Contradicting (0)

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No contradicting evidence found

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Source Study

Disease-Associated Mutation A554V Disrupts Normal Autoinhibition of DNMT1

Score: 4

DOI: 10.3390/dna3030010

Similar Assertions

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