A specific genetic change called A554V makes a protein that controls DNA tagging work much faster than normal.

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Against

Evidence from Studies

Supporting (1)

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Community contributions welcome

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Disease-Associated Mutation A554V Disrupts Normal Autoinhibition of DNMT1

Cross-Sectional Study

In Vitro

2023 Sep

Scientists tested the A554V mutation and found it makes DNMT1 more active - the mutant version binds DNA better and adds more methyl groups compared to the normal version, exactly as the claim describes.

Contradicting (0)

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Disease-Associated Mutation A554V Disrupts Normal Autoinhibition of DNMT1

Score: 4

DOI: 10.3390/dna3030010

Similar Assertions

Scientists found that a specific genetic change called A554V in a protein called DNMT1 makes it stick to DNA about 8 times tighter than normal.

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81%

A specific genetic change called A554V messes up a natural 'brake' on a protein that copies DNA patterns, making it harder for two parts of that protein to stick together properly.

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78%