mechanistic
Analysis v1
Strong Support
The gut, not the liver, is the main control center that tells the liver when to stop making bile acids — when bile acids enter gut cells, they trigger a signal (FGF15) that shuts down bile acid production in the liver.
12
0
Evidence from Studies
Supporting (1)
12
Community contributions welcome
12
Deletion of the ileal basolateral bile acid transporter identifies the cellular sentinels that regulate the bile acid pool
Case-Control Study
Animal
2008 Apr 1This study shows that when the intestine can't move bile acids back to the liver properly, the liver starts making too many bile acids—proving the intestine, not the liver, is the main control center for stopping bile acid production.
Contradicting (0)
0
Community contributions welcome
No contradicting evidence found
Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.