When mice can’t send bile acids out of their gut cells, the bile acids pile up inside the cells, tricking the body into thinking there’s too much bile acid overall — so the liver stops making more, even though the total amount in the body actually goes down.

12

Pro

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Against

Evidence from Studies

Supporting (1)

12

Community contributions welcome

12

Deletion of the ileal basolateral bile acid transporter identifies the cellular sentinels that regulate the bile acid pool

Case-Control Study

Animal

2008 Apr 1

When mice lose a specific transporter in their gut that moves bile acids out of intestinal cells, bile builds up inside those cells but drops in the body, which tells the liver to make less bile — proving that this transporter is needed to signal the liver to slow down bile production.

Contradicting (0)

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Deletion of the ileal basolateral bile acid transporter identifies the cellular sentinels that regulate the bile acid pool

Score: 12

DOI: 10.1073/pnas.0801194105

Similar Assertions

When mice lose a specific protein (Ostα/Ostβ) in their lower intestine, bile acids get stuck inside the gut cells instead of going back to the liver, which messes up the whole recycling system and reduces the total amount of bile acids in the body.

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83%

The gut, not the liver, is the main control center that tells the liver when to stop making bile acids — when bile acids enter gut cells, they trigger a signal (FGF15) that shuts down bile acid production in the liver.

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82%

Only a small part of the mouse’s lower intestine — the very end of the small bowel — has the special cells that detect bile acids and send signals to the liver to control how much is made.

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76%