When mice lose a specific protein (Ostα/Ostβ) in their lower intestine, bile acids get stuck inside the gut cells instead of going back to the liver, which messes up the whole recycling system and reduces the total amount of bile acids in the body.

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Evidence from Studies

Supporting (1)

12

Community contributions welcome

12

Deletion of the ileal basolateral bile acid transporter identifies the cellular sentinels that regulate the bile acid pool

Case-Control Study

Animal

2008 Apr 1

Scientists removed a specific protein (Ostα) in mice that helps move bile acids out of the intestine into the blood. When they did, bile acids got stuck inside the gut cells, less made it back to the liver, and the overall bile acid amount dropped — proving this protein is the main gate for moving bile acids out of the gut.

Contradicting (0)

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No contradicting evidence found

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Source Study

Deletion of the ileal basolateral bile acid transporter identifies the cellular sentinels that regulate the bile acid pool

Score: 12

DOI: 10.1073/pnas.0801194105

Similar Assertions

When mice can’t send bile acids out of their gut cells, the bile acids pile up inside the cells, tricking the body into thinking there’s too much bile acid overall — so the liver stops making more, even though the total amount in the body actually goes down.

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83%

Only a small part of the mouse’s lower intestine — the very end of the small bowel — has the special cells that detect bile acids and send signals to the liver to control how much is made.

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75%