The heart of mice with excess glucose uptake has less of a specific healthy fat in its mitochondria
Scientific Claim
Cardiolipin in heart tissue of mice with excess glucose uptake shows reduced C22:6 content
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study demonstrates an association between excess glucose uptake and reduced C22:6 in cardiac cardiolipin in mice. The language 'shows reduced' is appropriate for this mouse model study.
More Accurate Statement
“Cardiolipin in heart tissue of mice with excess glucose uptake is associated with reduced C22:6 content”
Source Excerpt
“We found the cardiac lipid content show the same trend as that of BAT. Although different lipid species have different relative contents of various acylchains, there was a general trend of less C22:6 in the KO, including cardiolipin (Figures 4K–4O; Figure S4D)”
Evidence from Studies
Supporting Evidence (1)
Lipidomics analysis specifically showed reduced C22:6 in cardiac cardiolipin of TXNIP KO mice compared to WT, indicating systemic effects of excess glucose on mitochondrial lipids.
Excess dietary carbohydrate affects mitochondrial integrity as observed in brown adipose tissue