Too much sugar breaks tiny power plants in fat cells
Excess dietary carbohydrate affects mitochondrial integrity as observed in brown adipose tissue
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
When mice eat too much sugar, their fat cells' mitochondria get damaged because they don't have enough healthy fats in their membranes. This makes them cold and weak. Giving them a high-fat, low-carb diet fixes the problem.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 5Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
When mice eat too much sugar, their fat cells' mitochondria get damaged because they don't have enough healthy fats in their membranes. This makes them cold and weak. Giving them a high-fat, low-carb diet fixes the problem.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 5Publication
Journal
Cell reports
Year
2021
Authors
Althea N. Waldhart, Brejnev Muhire, B. Johnson, Dean J. Pettinga, Z. Madaj, Emily Wolfrum, Holly Dykstra, Vanessa Wegert, J. Pospisilik, Xianlin Han, Ning Wu
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Claims (10)
When mice can't control how much glucose enters their cells, their fat-burning tissue doesn't work as well in the cold because the mitochondria don't have enough healthy fats in their membranes
When mice with excess glucose uptake eat a very low-carb diet, their fat-burning tissue works better in the cold because the diet changes the types of fats in their mitochondria
When too much glucose enters fat cells, they stop making the proteins needed to get and build healthy fats for mitochondria
When fat cells get too much glucose, their mitochondria become stiffer because the fats in their membranes change
When fat cells make too many saturated fats from glucose, these fats travel through the blood to other organs like the heart