When fat cells make too many saturated fats from glucose, these fats travel through the blood to other organs like the heart
Scientific Claim
Inter-tissue lipid flux distributes altered acyl-chain composition from lipogenic tissues to non-lipogenic tissues like heart
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study demonstrates an association between excess glucose uptake and altered lipid composition in distant tissues in mice. The language 'distributes' is appropriate for this mouse model study.
More Accurate Statement
“Inter-tissue lipid flux is associated with distribution of altered acyl-chain composition from lipogenic tissues to non-lipogenic tissues like heart”
Source Excerpt
“Due to the inter-tissue lipid flux, we suspected that the shorter and more saturated acyl-chains synthesized from excess glucose are distributed throughout the body. To verify this, we performed lipidomics analysis of the heart, which is not known to carry out significant lipogenesis. We found the cardiac lipid content show the same trend as that of BAT”
Evidence from Studies
Supporting Evidence (1)
Lipidomics analysis showed similar C22:6 reduction in heart tissue of TXNIP KO mice despite no expression changes in fatty acid metabolism genes in heart tissue, indicating systemic distribution of altered lipid composition.
Excess dietary carbohydrate affects mitochondrial integrity as observed in brown adipose tissue