When fat cells get too much glucose, their mitochondria become stiffer because the fats in their membranes change
Scientific Claim
Brown adipose tissue mitochondria from mice with excess glucose uptake show decreased membrane fluidity due to altered lipid composition
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study demonstrates an association between excess glucose uptake and decreased membrane fluidity in mice. The language 'show decreased' is appropriate for this mouse model study.
More Accurate Statement
“Brown adipose tissue mitochondria from mice with excess glucose uptake are associated with decreased membrane fluidity due to altered lipid composition”
Source Excerpt
“Mitochondria isolated from KO mice did have higher GP than those from WT (Figure 4F). At the same time, we saw the rescue of the difference by the ketogenic diet”
Evidence from Studies
Supporting Evidence (1)
Laurdan fluorescence measurements showed higher GP values (indicating lower fluidity) in KO mitochondria compared to WT. This difference was reversed by ketogenic diet, correlating with lipidomics data showing reduced C22:6 in PE.
Excess dietary carbohydrate affects mitochondrial integrity as observed in brown adipose tissue