When fat cells get too much glucose, their mitochondria become stiffer because the fats in their membranes change
Scientific Claim
Brown adipose tissue mitochondria from mice with excess glucose uptake show decreased membrane fluidity due to altered lipid composition
Original Statement
“Mitochondria isolated from KO mice did have higher GP than those from WT (Figure 4F). At the same time, we saw the rescue of the difference by the ketogenic diet”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study demonstrates an association between excess glucose uptake and decreased membrane fluidity in mice. The language 'show decreased' is appropriate for this mouse model study.
More Accurate Statement
“Brown adipose tissue mitochondria from mice with excess glucose uptake are associated with decreased membrane fluidity due to altered lipid composition”
Evidence from Studies
Supporting (1)
Excess dietary carbohydrate affects mitochondrial integrity as observed in brown adipose tissue