When too much glucose enters fat cells, they stop making the proteins needed to get and build healthy fats for mitochondria
Scientific Claim
Excess glucose uptake in brown adipose tissue reduces expression of genes involved in polyunsaturated fatty acid transport and elongation (MFSD2A, ELOVL3, ELOVL4, HACD2, LCLAT1)
Original Statement
“Five genes stood out that exhibited a significant cold-induced expression increase: Mfsd2A, Elovl 3, Elovl 4, Hacd2, and Lclat1. MFSD2A is the sole lipid transporter known to specifically transport PUFAs; ELOVL3 and ELOVL4 carry out the first rate-limiting condensation step in fatty acid elongation; HACD2 catalyzes the dehydration step; and LCLAT1 catalyzes the cardiolipin remodeling step”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study demonstrates an association between excess glucose uptake and reduced gene expression in mice. The language 'reduces' is appropriate for this mouse model study.
More Accurate Statement
“Excess glucose uptake in brown adipose tissue is associated with reduced expression of genes involved in polyunsaturated fatty acid transport and elongation (MFSD2A, ELOVL3, ELOVL4, HACD2, LCLAT1)”
Evidence from Studies
Supporting (1)
Excess dietary carbohydrate affects mitochondrial integrity as observed in brown adipose tissue