When mice with excess glucose uptake eat a very low-carb diet, their fat-burning tissue works better in the cold because the diet changes the types of fats in their mitochondria

When only fat cells lack TXNIP, they show the same mitochondrial problems as when the whole body lacks TXNIP

When mice can't control how much glucose enters their cells, their fat-burning tissue doesn't work as well in the cold because the mitochondria don't have enough healthy fats in their membranes