When only fat cells lack TXNIP, they show the same mitochondrial problems as when the whole body lacks TXNIP
Scientific Claim
Adipose-specific TXNIP knockout mice replicate the mitochondrial defects observed in total TXNIP knockout mice
Original Statement
“We generated adipocyte-specific TXNIP KO mice using AdipoQ-Cre (AKO). Like the total KO animals, AKO mice showed a faster clearance of glucose and more fat mass, consistent with higher lipogenesis induced by glucose absorption. We checked the mRNAs of Elovl3, Elovl4, and Mfsd2a in AKO mice and found the same results as in the total KOs”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study demonstrates an association between adipocyte-specific TXNIP knockout and mitochondrial defects in mice. The language 'replicate' is appropriate for this mouse model study.
More Accurate Statement
“Adipose-specific TXNIP knockout mice are associated with mitochondrial defects that replicate those observed in total TXNIP knockout mice”
Evidence from Studies
Supporting (1)
Excess dietary carbohydrate affects mitochondrial integrity as observed in brown adipose tissue