The human body converts only a small amount of alpha-linolenic acid (ALA) into EPA and DHA, so consuming EPA and DHA directly from food or supplements is necessary to reach levels required for normal...
Mechanism
Synthesis from 1 study
The body can't make enough of the important omega-3 fats from plant sources because the enzymes that convert them are too slow and get blocked by other common fats in the diet. That's why eating fish or other direct sources of these fats is needed to get enough for health.
Most probable mechanism
The body tries to turn plant-based omega-3s into the long-chain forms needed for health, but the enzymes that do this work are slow, easily overwhelmed by other fats, and genetically limited in many people, so very little of the plant omega-3 becomes the active forms in the body.
Alpha-linolenic acid (ALA) is absorbed from the diet and transported to the liver and other tissues.
ALA undergoes sequential elongation and desaturation by delta-6 and delta-5 desaturase enzymes to form eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).
Delta-5 desaturase activity is genetically constrained in many individuals, reducing the efficiency of EPA and DHA synthesis from ALA.
Linoleic acid (LA), abundant in Western diets, competes with ALA for the same desaturase enzymes, further limiting ALA conversion.
The resulting EPA and DHA production rates are insufficient to maintain physiologically relevant tissue concentrations without direct dietary intake.
Evidence from Studies
Supporting (1)
Community contributions welcome
ω-6 and ω-3 Polyunsaturated Fatty Acids: Inflammation, Obesity and Foods of Animal Resources
Contradicting (0)
Community contributions welcome
Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.